6M71

SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors

Summary for 6M71

• Entry DOI: 10.2210/pdb6m71/pdb
• EMDB information: 30127
• Descriptor: RNA-directed RNA polymerase, Non-structural protein 7, Non-structural protein 8 (3 entities in total)
• Functional Keywords: covid-19, 2019-ncov, sars-cov-2, virus, rdrp, nsp12, nsp7, nsp8, rtc, cryo-em, viral protein, rna polymerase, drug target, antiviral, replication transcription complex
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 4
• Total formula weight: 161217.36

Authors

Gao, Y.,Yan, L.,Huang, Y.,Liu, F.,Cao, L.,Wang, T.,Wang, Q.,Lou, Z.,Rao, Z. (deposition date: 2020-03-16, release date: 2020-04-01, Last modification date: 2021-03-10)

• Primary citation: Gao, Y.,Yan, L.,Huang, Y.,Liu, F.,Zhao, Y.,Cao, L.,Wang, T.,Sun, Q.,Ming, Z.,Zhang, L.,Ge, J.,Zheng, L.,Zhang, Y.,Wang, H.,Zhu, Y.,Zhu, C.,Hu, T.,Hua, T.,Zhang, B.,Yang, X.,Li, J.,Yang, H.,Liu, Z.,Xu, W.,Guddat, L.W.,Wang, Q.,Lou, Z.,Rao, Z.; Structure of the RNA-dependent RNA polymerase from COVID-19 virus.; Science, 368:779-782, 2020; PubMed: 32277040; DOI: 10.1126/science.abb7498

Experimental method

ELECTRON MICROSCOPY (2.9 Å)