6M6K

NMR solution structure of a DNA minidumbbell containing an abasic bulge between two CCTG repeats

Summary for 6M6K

• Entry DOI: 10.2210/pdb6m6k/pdb
• NMR Information: BMRB: 36326
• Descriptor: DNA (5'-D(*CP*TP*TP*GP*(3DR)P*CP*TP*TP*G)-3'), SODIUM ION (2 entities in total)
• Functional Keywords: minidumbbell, abasic site, bulge, cc mispair, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 2742.58

Authors

Wan, L.,Lam, S.L.,Guo, P. (deposition date: 2020-03-15, release date: 2020-07-29, Last modification date: 2024-05-01)

Primary citation

Wan, L.,Lam, S.L.,Lee, H.K.,Guo, P.
Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell.
Chem.Commun.(Camb.), 56:10127-10130, 2020

PubMed Abstract: Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.

PubMed: 32870195
DOI: 10.1039/d0cc03774e

Experimental method

SOLUTION NMR