6M5W
Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Summary for 6M5W
Entry DOI | 10.2210/pdb6m5w/pdb |
Descriptor | Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 56038.65 |
Authors | Ota, T.,Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. (deposition date: 2020-03-11, release date: 2021-01-20, Last modification date: 2023-11-29) |
Primary citation | Ota, T.,Senoo, A.,Shirakawa, M.,Nonaka, H.,Saito, Y.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. Iscience, 24:102036-102036, 2021 Cited by PubMed: 33521601DOI: 10.1016/j.isci.2021.102036 PDB entries with the same primary citation |
Experimental method |
Structure validation
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