6M2B

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416

6M2B の概要

• エントリーDOI: 10.2210/pdb6m2b/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, biosynthetic protein, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43620.69

構造登録者

Zhu, L.,Li, H. (登録日: 2020-02-27, 公開日: 2021-03-03, 最終更新日: 2023-11-29)

• 主引用文献: Xiong, R.,Zhang, L.,Li, S.,Sun, Y.,Ding, M.,Wang, Y.,Zhao, Y.,Wu, Y.,Shang, W.,Jiang, X.,Shan, J.,Shen, Z.,Tong, Y.,Xu, L.,Chen, Y.,Liu, Y.,Zou, G.,Lavillete, D.,Zhao, Z.,Wang, R.,Zhu, L.,Xiao, G.,Lan, K.,Li, H.,Xu, K.; Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.; Protein Cell, 11:723-739, 2020; PubMed: 32754890; DOI: 10.1007/s13238-020-00768-w

実験手法

X-RAY DIFFRACTION (1.76 Å)