6M1K

USP7 in complex with a novel inhibitor

6M1K の概要

• エントリーDOI: 10.2210/pdb6m1k/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate (3 entities in total)
• 機能のキーワード: inhibitor, complex, usp7, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81450.90

構造登録者

Liu, S.J.,Zhou, X.Y.,Li, M.L.,Sun, H.B.,Wen, X.A. (登録日: 2020-02-26, 公開日: 2021-03-10, 最終更新日: 2023-11-29)

• 主引用文献: Li, M.,Liu, S.,Chen, H.,Zhou, X.,Zhou, J.,Zhou, S.,Yuan, H.,Xu, Q.L.,Liu, J.,Cheng, K.,Sun, H.,Wang, Y.,Chen, C.,Wen, X.; N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.; Eur.J.Med.Chem., 199:112279-112279, 2020; PubMed: 32497973; DOI: 10.1016/j.ejmech.2020.112279

実験手法

X-RAY DIFFRACTION (2.255 Å)