6M13

Crystal structure of Rnase L in complex with Toceranib

Summary for 6M13

• Entry DOI: 10.2210/pdb6m13/pdb
• Related: 6M11 6M12
• Descriptor: Ribonuclease L, 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, ... (5 entities in total)
• Functional Keywords: inhibitor, kinase, rnase l, toceranib, hydrolase
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 2
• Total formula weight: 165874.74

Authors

Tang, J.,Huang, H. (deposition date: 2020-02-24, release date: 2020-09-02, Last modification date: 2023-11-29)

• Primary citation: Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H.; Sunitinib inhibits RNase L by destabilizing its active dimer conformation.; Biochem.J., 477:3387-3399, 2020; PubMed: 32830849; DOI: 10.1042/BCJ20200260

Experimental method

X-RAY DIFFRACTION (2.56 Å)