6LZC

crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05

6LZC の概要

• エントリーDOI: 10.2210/pdb6lzc/pdb
• 分子名称: Methionine aminopeptidase 1, COBALT (II) ION, ~{N}-oxidanyl-1-(phenylmethyl)pyrrolo[2,3-b]pyridine-4-carboxamide, ... (7 entities in total)
• 機能のキーワード: methionine aminopeptidase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37644.65

構造登録者

Sandeep, C.B.,Addlagatta, A. (登録日: 2020-02-18, 公開日: 2021-02-24, 最終更新日: 2023-11-29)

• 主引用文献: Bala, S.,Yellamanda, K.V.,Kadari, A.,Ravinuthala, V.S.U.,Kattula, B.,Singh, O.V.,Gundla, R.,Addlagatta, A.; Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies.; Bioorg.Chem., 115:105185-105185, 2021; PubMed: 34329997; DOI: 10.1016/j.bioorg.2021.105185

実験手法

X-RAY DIFFRACTION (1.35 Å)