6LUB
Crystal Structure of EGFR(L858R/T790M/C797S) in complex with CH7233163
Summary for 6LUB
| Entry DOI | 10.2210/pdb6lub/pdb |
| Descriptor | Epidermal growth factor receptor, N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine (3 entities in total) |
| Functional Keywords | protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 38001.87 |
| Authors | Kawauchi, H.,Fukami, T.A.,Sato, S.,Endo, M.,Torizawa, T.,Kashima, K.,Chiba, T.,Sakamoto, H. (deposition date: 2020-01-27, release date: 2020-10-07, Last modification date: 2023-11-29) |
| Primary citation | Kashima, K.,Kawauchi, H.,Tanimura, H.,Tachibana, Y.,Chiba, T.,Torizawa, T.,Sakamoto, H. CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation. Mol.Cancer Ther., 19:2288-2297, 2020 Cited by PubMed: 32943545DOI: 10.1158/1535-7163.MCT-20-0229 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.315 Å) |
Structure validation
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