6LTV

Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine)

Summary for 6LTV

Entry DOI	10.2210/pdb6ltv/pdb
Descriptor	S-adenosylmethionine synthase, TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	triphosphate, s-adenosylmethionine synthetase, transferase
Biological source	Cryptosporidium hominis
Total number of polymer chains	2
Total formula weight	93347.93
Authors	Singh, R.K.,Michailidou, F.,Rentmeister, A.,Kuemmel, D. (deposition date: 2020-01-23, release date: 2020-10-21, Last modification date: 2023-11-29)
Primary citation	Michailidou, F.,Klocker, N.,Cornelissen, N.V.,Singh, R.K.,Peters, A.,Ovcharenko, A.,Kummel, D.,Rentmeister, A. Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew.Chem.Int.Ed.Engl., 60:480-485, 2021 Cited by PubMed: 33017502 DOI: 10.1002/anie.202012623 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation