6LR9

HSP90 in complex with Debio0932

Summary for 6LR9

Entry DOI	10.2210/pdb6lr9/pdb
Descriptor	Heat shock protein HSP 90-alpha, 2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]sulfanyl]-1-[2-(2,2-dimethylpropylamino)ethyl]imidazo[4,5-c]pyridin-4-amine, GLYCEROL, ... (4 entities in total)
Functional Keywords	hsp90, debio0932, chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28935.37
Authors	Cao, H.L. (deposition date: 2020-01-15, release date: 2021-01-13, Last modification date: 2023-11-29)
Primary citation	Qin, W.,Yu, F.,Zhou, H.,Li, P.,Zhou, F.,Li, H.J.,He, C.X.,Xing, L.,Zhou, X.,Zhao, D.,Li, P.Q.,Jin, X.,Wang, Q.S.,He, J.H.,Cao, H.L. Complex crystal structure determination and anti-non-small-cell lung cancer activity of the Hsp90 N inhibitor Debio0932. Acta Crystallogr D Struct Biol, 77:86-97, 2021 Cited by PubMed: 33404528 DOI: 10.1107/S2059798320014990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.196 Å)

Structure validation