6LLX

Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma

Summary for 6LLX

• Entry DOI: 10.2210/pdb6llx/pdb
• Related: 6LLC
• Descriptor: Glutathione S-transferase P, GLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: oxidative stress, nqo1, gstp1, gbm, small molecular inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 48789.81

Authors

Ye, K.,Li, H.,Lei, K.C. (deposition date: 2019-12-24, release date: 2020-11-25, Last modification date: 2023-11-22)

• Primary citation: Lei, K.,Gu, X.,Alvarado, A.G.,Du, Y.,Luo, S.,Ahn, E.H.,Kang, S.S.,Ji, B.,Liu, X.,Mao, H.,Fu, H.,Kornblum, H.I.,Jin, L.,Li, H.,Ye, K.; Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.; J Hematol Oncol, 13:141-141, 2020; PubMed: 33087132; DOI: 10.1186/s13045-020-00979-y

Experimental method

X-RAY DIFFRACTION (1.581 Å)