6LLC

Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma

6LLC の概要

• エントリーDOI: 10.2210/pdb6llc/pdb
• 分子名称: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, 5-methyl-N-(5-nitro-1,3-thiazol-2-yl)-3-phenyl-1,2-oxazole-4-carboxamide, ... (5 entities in total)
• 機能のキーワード: oxidative stress, gbm, small molecular inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 381770.35

構造登録者

Ye, K.,Li, H. (登録日: 2019-12-23, 公開日: 2020-11-25, 最終更新日: 2023-11-22)

• 主引用文献: Lei, K.,Gu, X.,Alvarado, A.G.,Du, Y.,Luo, S.,Ahn, E.H.,Kang, S.S.,Ji, B.,Liu, X.,Mao, H.,Fu, H.,Kornblum, H.I.,Jin, L.,Li, H.,Ye, K.; Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.; J Hematol Oncol, 13:141-141, 2020; PubMed: 33087132; DOI: 10.1186/s13045-020-00979-y

実験手法

X-RAY DIFFRACTION (2.501 Å)