6LJW

Crystal structure of human FABP4 in complex with a novel inhibitor

Summary for 6LJW

Entry DOI	10.2210/pdb6ljw/pdb
Descriptor	Fatty acid-binding protein, adipocyte, 2-phenylazanylbenzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	fabp4, inhibitor, complex, lipid binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	17186.57
Authors	Su, H.X.,Zhang, X.L.,Li, M.J.,Xu, Y.C. (deposition date: 2019-12-17, release date: 2020-04-15, Last modification date: 2023-11-22)
Primary citation	Su, H.,Zou, Y.,Chen, G.,Dou, H.,Xie, H.,Yuan, X.,Zhang, X.,Zhang, N.,Li, M.,Xu, Y. Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. J.Med.Chem., 63:4090-4106, 2020 Cited by PubMed: 32202425 DOI: 10.1021/acs.jmedchem.9b02107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation