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6LIL

Crystal structure of human PDK2 complexed with an allosteric inhibitor compound 8c

Summary for 6LIL
Entry DOI10.2210/pdb6lil/pdb
Descriptor[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywordsmitochondria, kinase, inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight94270.88
Authors
Kang, J.,Kim, J. (deposition date: 2019-12-12, release date: 2020-09-30, Last modification date: 2023-11-22)
Primary citationKang, J.,Pagire, H.S.,Kang, D.,Song, Y.H.,Lee, I.K.,Lee, K.T.,Park, C.J.,Ahn, J.H.,Kim, J.
Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds.
Biochem.Biophys.Res.Commun., 527:778-784, 2020
Cited by
PubMed: 32444142
DOI: 10.1016/j.bbrc.2020.04.102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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