6LG9

crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2143

Summary for 6LG9

• Entry DOI: 10.2210/pdb6lg9/pdb
• Descriptor: Bromodomain-containing protein 4, 2-azanyl-7-bromanyl-4-imidazol-1-yl-quinolin-8-ol (3 entities in total)
• Functional Keywords: brd4, inhibitor, complex, dna binding protein, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15188.32

Authors

Xu, H.,Zuo, Y. (deposition date: 2019-12-04, release date: 2020-12-09, Last modification date: 2023-11-22)

• Primary citation: Xu, H.,Zuo, Y.,Luo, C.,Zhang, H.; Lead-Opt: An efficient tool for structural optimization of lead compounds; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.81 Å)