6LEM

Structure of E. coli beta-glucuronidase complex with C6-nonyl uronic isofagomine

Summary for 6LEM

• Entry DOI: 10.2210/pdb6lem/pdb
• Descriptor: Beta-D-glucuronidase, (2~{S},3~{S},4~{R},5~{R})-2-nonyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid (3 entities in total)
• Functional Keywords: inhibitor, isofagomine, glycosidase, hydrolase
• Biological source: Escherichia coli; More
• Total number of polymer chains: 2
• Total formula weight: 137599.12

Authors

Lin, H.-Y.,Kuo, Y.-H.,Lin, C.-H. (deposition date: 2019-11-25, release date: 2021-01-27, Last modification date: 2023-11-22)

• Primary citation: Lin, H.Y.,Chen, C.Y.,Lin, T.C.,Yeh, L.F.,Hsieh, W.C.,Gao, S.,Burnouf, P.A.,Chen, B.M.,Hsieh, T.J.,Dashnyam, P.,Kuo, Y.H.,Tu, Z.,Roffler, S.R.,Lin, C.H.; Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity.; Commun Biol, 4:280-280, 2021; PubMed: 33664385; DOI: 10.1038/s42003-021-01815-w

Experimental method

X-RAY DIFFRACTION (3.188 Å)