6LEG
Structure of E. coli beta-glucuronidase complex with uronic isofagomine
Summary for 6LEG
Entry DOI | 10.2210/pdb6leg/pdb |
Descriptor | Beta-D-glucuronidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid (3 entities in total) |
Functional Keywords | inhibitor, isofagomine, glycosidase, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 4 |
Total formula weight | 275284.12 |
Authors | Lin, H.-Y.,Kuo, Y.-H.,Lin, C.-H. (deposition date: 2019-11-25, release date: 2021-01-27, Last modification date: 2023-11-22) |
Primary citation | Lin, H.Y.,Chen, C.Y.,Lin, T.C.,Yeh, L.F.,Hsieh, W.C.,Gao, S.,Burnouf, P.A.,Chen, B.M.,Hsieh, T.J.,Dashnyam, P.,Kuo, Y.H.,Tu, Z.,Roffler, S.R.,Lin, C.H. Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4:280-280, 2021 Cited by PubMed: 33664385DOI: 10.1038/s42003-021-01815-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.603 Å) |
Structure validation
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