6LCS

Crystal structure of 73MuL9 Fv-clasp fragment in complex with GA-pyridine analogue

Summary for 6LCS

• Entry DOI: 10.2210/pdb6lcs/pdb
• Descriptor: VH-SARAH, VL-SARAH, (2~{S})-6-[4-(hydroxymethyl)-3-oxidanyl-pyridin-1-ium-1-yl]-2-(phenylmethoxycarbonylamino)hexanoic acid, ... (5 entities in total)
• Functional Keywords: age, antibody fragment, fv-clasp, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 2
• Total formula weight: 38666.98

Authors

Nakamura, T.,Takagi, J.,Yamagata, Y.,Morioka, H. (deposition date: 2019-11-19, release date: 2020-11-25, Last modification date: 2023-11-22)

• Primary citation: Kobashigawa, Y.,Ohara, T.,Morita, K.,Toyota, Y.,Nakamura, T.,Kotani, S.,Arimori, T.,Yamauchi, S.,Liu, C.,Kitazaki, M.,Wakeyama-Miyazaki, Y.,Suwa, Y.,Uchida-Kamekura, M.,Fukuda, N.,Sato, T.,Nakajima, M.,Takagi, J.,Yamagata, Y.,Morioka, H.; Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues.; J.Biochem., 170:379-387, 2021; PubMed: 34185078; DOI: 10.1093/jb/mvab056

Experimental method

X-RAY DIFFRACTION (2.6 Å)