6L7L

Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide

6L7L の概要

• エントリーDOI: 10.2210/pdb6l7l/pdb
• 分子名称: Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 154936.97

構造登録者

Miyahara, S.,Chong, K.T.,Suzuki, T. (登録日: 2019-11-01, 公開日: 2020-11-04, 最終更新日: 2023-11-22)

• 主引用文献: Miyahara, S.,Hara, S.,Chong, K.T.,Suzuki, T.,Ogino, Y.,Hoshino, T.,Tsukioka, S.,Yano, W.,Suzuki, M.,Otsu, Y.,Yonekura, T.,Ito, S.,Terasaka, M.,Suzuki, T.,Hashimoto, A.; TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity; To be published,

実験手法

X-RAY DIFFRACTION (2.171 Å)