6L59

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.

6L59 の概要

• エントリーDOI: 10.2210/pdb6l59/pdb
• 分子名称: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: tca cycle, nad-isocitrate dehydrogenase, oxidoreductase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77355.44

構造登録者

Sun, P.,Ding, J. (登録日: 2019-10-22, 公開日: 2020-04-29, 最終更新日: 2023-11-22)

• 主引用文献: Sun, P.,Bai, T.,Ma, T.,Ding, J.; Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.; Sci Rep, 10:6225-6225, 2020; PubMed: 32277159; DOI: 10.1038/s41598-020-63425-6

実験手法

X-RAY DIFFRACTION (2.254 Å)