6L47

Structure of the human sterol O-acyltransferase 1 in complex with CI-976

Summary for 6L47

• Entry DOI: 10.2210/pdb6l47/pdb
• EMDB information: 0831
• Descriptor: Sterol O-acyltransferase 1, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CHOLESTEROL (3 entities in total)
• Functional Keywords: soat, acat, mboat, membrane protein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 116149.98

Authors

Chen, L.,Guan, C.,Niu, Y. (deposition date: 2019-10-16, release date: 2020-04-29, Last modification date: 2020-10-07)

• Primary citation: Guan, C.,Niu, Y.,Chen, S.C.,Kang, Y.,Wu, J.X.,Nishi, K.,Chang, C.C.Y.,Chang, T.Y.,Luo, T.,Chen, L.; Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor.; Nat Commun, 11:2478-2478, 2020; PubMed: 32424158; DOI: 10.1038/s41467-020-16288-4

Experimental method

ELECTRON MICROSCOPY (3.5 Å)