6L3Y

Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-C

Summary for 6L3Y

• Entry DOI: 10.2210/pdb6l3y/pdb
• Related: 4PG3
• Descriptor: Lysine--tRNA ligase, LYSINE, (3R)-3-[[(3S)-3-ethylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, ... (5 entities in total)
• Functional Keywords: inhibitor, cladosporin analog, stereochemistry, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 2
• Total formula weight: 118793.85

Authors

Babbar, P.,Sharma, A.,Mishra, S.,Manickam, Y.,Harlos, K. (deposition date: 2019-10-15, release date: 2021-05-19, Last modification date: 2023-11-22)

• Primary citation: Babbar, P.,Sato, M.,Manickam, Y.,Mishra, S.,Harlos, K.,Gupta, S.,Parvez, S.,Kikuchi, H.,Sharma, A.; Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B; Chembiochem, 2021; DOI: 10.1002/cbic.202100212

Experimental method

X-RAY DIFFRACTION (3.1 Å)