6KZD

Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide

Summary for 6KZD

Entry DOI	10.2210/pdb6kzd/pdb
Descriptor	NT-3 growth factor receptor, 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	trkc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36505.30
Authors	Wang, Y.,Zhang, Z.M. (deposition date: 2019-09-23, release date: 2019-10-09, Last modification date: 2024-03-27)
Primary citation	Cui, S.,Wang, Y.,Wang, Y.,Tang, X.,Ren, X.,Zhang, L.,Xu, Y.,Zhang, Z.,Zhang, Z.M.,Lu, X.,Ding, K. Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem., 179:470-482, 2019 Cited by PubMed: 31271959 DOI: 10.1016/j.ejmech.2019.06.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.708 Å)

Structure validation