6KZD

Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide

6KZD の概要

• エントリーDOI: 10.2210/pdb6kzd/pdb
• 分子名称: NT-3 growth factor receptor, 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: trkc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36505.30

構造登録者

Wang, Y.,Zhang, Z.M. (登録日: 2019-09-23, 公開日: 2019-10-09, 最終更新日: 2024-03-27)

• 主引用文献: Cui, S.,Wang, Y.,Wang, Y.,Tang, X.,Ren, X.,Zhang, L.,Xu, Y.,Zhang, Z.,Zhang, Z.M.,Lu, X.,Ding, K.; Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.; Eur.J.Med.Chem., 179:470-482, 2019; PubMed: 31271959; DOI: 10.1016/j.ejmech.2019.06.064

実験手法

X-RAY DIFFRACTION (1.708 Å)