6KXH

Alp1U_Y247F mutant in complex with Fluostatin C

Summary for 6KXH

• Entry DOI: 10.2210/pdb6kxh/pdb
• Related: 6kxc
• Descriptor: Putative hydrolase, Fluostatin C, D-MALATE, ... (5 entities in total)
• Functional Keywords: hydrolyse epoxide, cis-vicinal diol, hydrolase
• Biological source: Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL B-2516)
• Total number of polymer chains: 4
• Total formula weight: 149773.94

Authors

Zhang, L.,Yingli, Z.,De, B.C.,Zhang, C. (deposition date: 2019-09-11, release date: 2020-09-16, Last modification date: 2024-03-27)

• Primary citation: Zhang, L.,De, B.C.,Zhang, W.,Mandi, A.,Fang, Z.,Yang, C.,Zhu, Y.,Kurtan, T.,Zhang, C.; Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha / beta-fold epoxide hydrolase Alp1U.; J.Biol.Chem., 295:16987-16997, 2020; PubMed: 33004437; DOI: 10.1074/jbc.RA120.015563

Experimental method

X-RAY DIFFRACTION (1.78039550258 Å)