6KVA

Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope

Summary for 6KVA

• Entry DOI: 10.2210/pdb6kva/pdb
• Descriptor: heavy chain, light chain, Peptide from C-X-C chemokine receptor type 2, ... (5 entities in total)
• Functional Keywords: antibody-antigen complex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 98407.56

Authors

Xiang, J.C.,Yan, L.,Yang, B.,Wilson, I.A. (deposition date: 2019-09-03, release date: 2020-09-09, Last modification date: 2023-11-22)

• Primary citation: Shi, X.,Wan, Y.,Wang, N.,Xiang, J.,Wang, T.,Yang, X.,Wang, J.,Dong, X.,Dong, L.,Yan, L.,Li, Y.,Liu, L.,Hou, S.,Zhong, Z.,Wilson, I.A.,Yang, B.,Yang, G.,Lerner, R.A.; Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.; Nat Commun, 12:2547-2547, 2021; PubMed: 33953162; DOI: 10.1038/s41467-021-22810-z

Experimental method

X-RAY DIFFRACTION (2.2 Å)