6KNR

Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699

6KNR の概要

• エントリーDOI: 10.2210/pdb6knr/pdb
• 分子名称: Estrogen-related receptor gamma, (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol (3 entities in total)
• 機能のキーワード: estrogen-related receptor gamma, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55747.14

構造登録者

Yoon, H.,Kim, J.,Chin, J.,Song, J.,Cho, S.J. (登録日: 2019-08-07, 公開日: 2020-08-12, 最終更新日: 2023-11-22)

• 主引用文献: Kim, J.,Hwang, H.,Yoon, H.,Lee, J.E.,Oh, J.M.,An, H.,Ji, H.D.,Lee, S.,Cha, E.,Ma, M.J.,Kim, D.S.,Lee, S.J.,Kadayat, T.M.,Song, J.,Lee, S.W.,Jeon, J.H.,Park, K.G.,Lee, I.K.,Jeon, Y.H.,Chin, J.,Cho, S.J.; An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.; Eur.J.Med.Chem., 205:112501-112501, 2020; PubMed: 32758860; DOI: 10.1016/j.ejmech.2020.112501

実験手法

X-RAY DIFFRACTION (2.804 Å)