6KGR
LSD1-FCPA-MPE N5 adduct model
Summary for 6KGR
Entry DOI | 10.2210/pdb6kgr/pdb |
Descriptor | Lysine-specific histone demethylase 1A, (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[4-[5-fluoranyl-2-(trifluoromethyl)phenyl]phenyl]propanal, ... (5 entities in total) |
Functional Keywords | demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 75533.02 |
Authors | Niwa, H.,Sato, S.,Handa, N.,Umehara, T. (deposition date: 2019-07-12, release date: 2020-03-25, Last modification date: 2024-03-27) |
Primary citation | Niwa, H.,Sato, S.,Handa, N.,Sengoku, T.,Umehara, T.,Yokoyama, S. Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors. Chemmedchem, 15:787-793, 2020 Cited by PubMed: 32166890DOI: 10.1002/cmdc.202000014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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