6KEK

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one

Summary for 6KEK

Entry DOI	10.2210/pdb6kek/pdb
Descriptor	Bromodomain-containing protein 4, FORMIC ACID, 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one, ... (4 entities in total)
Functional Keywords	brd4, bromodomain 1, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15642.70
Authors	Lee, B.I.,Park, T.H. (deposition date: 2019-07-04, release date: 2020-07-08, Last modification date: 2023-11-22)
Primary citation	Yoo, M.,Park, T.H.,Yoo, M.,Kim, Y.,Lee, J.Y.,Lee, K.M.,Ryu, S.E.,Lee, B.I.,Jung, K.Y.,Park, C.H. Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26:-, 2021 Cited by PubMed: 33802888 DOI: 10.3390/molecules26061686 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.553 Å)

Structure validation