6KEK
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue FMT A 201 |
Chain | Residue |
A | ILE100 |
A | LYS102 |
A | THR103 |
A | ASN135 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue FMT A 202 |
Chain | Residue |
A | ASN44 |
A | VAL87 |
A | ASP88 |
A | HOH303 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue FMT A 203 |
Chain | Residue |
A | ASN117 |
A | TYR118 |
A | TYR119 |
A | LEU114 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue FMT A 204 |
Chain | Residue |
A | ASP96 |
A | HOH307 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue FMT A 205 |
Chain | Residue |
A | THR60 |
A | GLN62 |
A | ASN121 |
A | ALA122 |
A | HOH331 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue FMT A 206 |
Chain | Residue |
A | PRO56 |
A | LYS57 |
A | LYS99 |
A | LYS102 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue FMT A 207 |
Chain | Residue |
A | THR60 |
A | ASN61 |
A | GLN62 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue D7L A 208 |
Chain | Residue |
A | TRP81 |
A | PRO82 |
A | GLN85 |
A | LEU92 |
A | ASP96 |
A | LYS99 |
A | ASN140 |
A | ILE146 |
A | HOH312 |
Functional Information from PROSITE/UniProt
site_id | PS00633 |
Number of Residues | 60 |
Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
Chain | Residue | Details |
A | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASN140 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS99 | |