6KEE

Crystal structure of BRD4 Bromodomain1 with an inhibitor

Summary for 6KEE

• Entry DOI: 10.2210/pdb6kee/pdb
• Descriptor: Bromodomain-containing protein 4, 6-[2-[2,4-bis(fluoranyl)phenoxy]-5-(methylsulfonylmethyl)pyridin-3-yl]-8-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one (3 entities in total)
• Functional Keywords: antitumor, bet proteins, bromodomain inhibitor, epigenetic readers, antitumor protein, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15544.82

Authors

Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C. (deposition date: 2019-07-04, release date: 2020-07-08, Last modification date: 2023-11-22)

• Primary citation: Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C.; Crystal structure of BRD4 Bromodomain1 with an inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.12154661767 Å)