6KEC

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one

6KEC の概要

• エントリーDOI: 10.2210/pdb6kec/pdb
• 分子名称: Bromodomain-containing protein 4, 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, FORMIC ACID, ... (4 entities in total)
• 機能のキーワード: brd4, bromodomain, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15562.70

構造登録者

Lee, B.I.,Park, T.H. (登録日: 2019-07-04, 公開日: 2020-07-08, 最終更新日: 2023-11-22)

• 主引用文献: Yoo, M.,Park, T.H.,Yoo, M.,Kim, Y.,Lee, J.Y.,Lee, K.M.,Ryu, S.E.,Lee, B.I.,Jung, K.Y.,Park, C.H.; Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research.; Molecules, 26:-, 2021; PubMed: 33802888; DOI: 10.3390/molecules26061686

実験手法

X-RAY DIFFRACTION (1.35 Å)