6K0T
Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-17
Summary for 6K0T
Entry DOI | 10.2210/pdb6k0t/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, 3-[(1~{E})-1-[8-[(8-chloranyl-2-cyclopropyl-imidazo[1,2-a]pyridin-3-yl)methyl]-3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene]ethyl]-4~{H}-1,2,4-oxadiazol-5-one, ... (4 entities in total) |
Functional Keywords | ppargamma, ligand binding domain, pparg modulator, cancer, nuclear protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 69309.13 |
Authors | Suzuki, M.,Yamamoto, K.,Takahashi, Y.,Saito, J. (deposition date: 2019-05-07, release date: 2019-10-30, Last modification date: 2019-11-06) |
Primary citation | Yamamoto, K.,Tamura, T.,Nakamura, R.,Hosoe, S.,Matsubara, M.,Nagata, K.,Kodaira, H.,Uemori, T.,Takahashi, Y.,Suzuki, M.,Saito, J.I.,Ueno, K.,Shuto, S. Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold. Bioorg.Med.Chem., 27:115122-115122, 2019 Cited by PubMed: 31623970DOI: 10.1016/j.bmc.2019.115122 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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