6K0J

The co-crystal structure of DYRK2 with a small molecule inhibitor

6K0J の概要

• エントリーDOI: 10.2210/pdb6k0j/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine (3 entities in total)
• 機能のキーワード: kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38099.10

構造登録者

Tiantian, W.,Xiao, J. (登録日: 2019-05-06, 公開日: 2019-11-20, 最終更新日: 2019-12-18)

• 主引用文献: Banerjee, S.,Wei, T.,Wang, J.,Lee, J.J.,Gutierrez, H.L.,Chapman, O.,Wiley, S.E.,Mayfield, J.E.,Tandon, V.,Juarez, E.F.,Chavez, L.,Liang, R.,Sah, R.L.,Costello, C.,Mesirov, J.P.,de la Vega, L.,Cooper, K.L.,Dixon, J.E.,Xiao, J.,Lei, X.; Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.; Proc.Natl.Acad.Sci.USA, 116:24881-24891, 2019; PubMed: 31754034; DOI: 10.1073/pnas.1912033116

実験手法

X-RAY DIFFRACTION (2.352 Å)