6JWT

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate

Summary for 6JWT

Entry DOI	10.2210/pdb6jwt/pdb
Descriptor	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... (8 entities in total)
Functional Keywords	tim barrel, kinase, transferase
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	173935.37
Authors	Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-04-21, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citation	Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287:3273-3297, 2020 Cited by PubMed: 31883412 DOI: 10.1111/febs.15196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation