6JWT

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate

6JWT の概要

• エントリーDOI: 10.2210/pdb6jwt/pdb
• 分子名称: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... (8 entities in total)
• 機能のキーワード: tim barrel, kinase, transferase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 173935.37

構造登録者

Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (登録日: 2019-04-21, 公開日: 2020-02-12, 最終更新日: 2023-11-22)

• 主引用文献: Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y.; The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.; Febs J., 287:3273-3297, 2020; PubMed: 31883412; DOI: 10.1111/febs.15196

実験手法

X-RAY DIFFRACTION (2.56 Å)