6JUX
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807
Summary for 6JUX
Entry DOI | 10.2210/pdb6jux/pdb |
Descriptor | Activin receptor type-1, 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34931.99 |
Authors | Sakai, N.,Mishima-Tsumagari, C.,Matsumoto, T.,Shirouzu, M. (deposition date: 2019-04-15, release date: 2020-04-15, Last modification date: 2023-11-22) |
Primary citation | Sato, T.,Sekimata, K.,Sakai, N.,Watanabe, H.,Mishima-Tsumagari, C.,Taguri, T.,Matsumoto, T.,Fujii, Y.,Handa, N.,Tanaka, A.,Shirouzu, M.,Yokoyama, S.,Hashizume, Y.,Miyazono, K.,Koyama, H.,Honma, T. Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches. Acs Omega, 5:11411-11423, 2020 Cited by PubMed: 32478230DOI: 10.1021/acsomega.9b04245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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