6JUX

Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807

6JUX の概要

• エントリーDOI: 10.2210/pdb6jux/pdb
• 分子名称: Activin receptor type-1, 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34931.99

構造登録者

Sakai, N.,Mishima-Tsumagari, C.,Matsumoto, T.,Shirouzu, M. (登録日: 2019-04-15, 公開日: 2020-04-15, 最終更新日: 2023-11-22)

• 主引用文献: Sato, T.,Sekimata, K.,Sakai, N.,Watanabe, H.,Mishima-Tsumagari, C.,Taguri, T.,Matsumoto, T.,Fujii, Y.,Handa, N.,Tanaka, A.,Shirouzu, M.,Yokoyama, S.,Hashizume, Y.,Miyazono, K.,Koyama, H.,Honma, T.; Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.; Acs Omega, 5:11411-11423, 2020; PubMed: 32478230; DOI: 10.1021/acsomega.9b04245

実験手法

X-RAY DIFFRACTION (1.75 Å)