6JUT

Crystal structure of ZAK in complex with compound 6k

6JUT の概要

• エントリーDOI: 10.2210/pdb6jut/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase MLT, ~{N}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamide (3 entities in total)
• 機能のキーワード: zak, inhibitor, structural protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35899.85

構造登録者

Kong, L.L.,Yun, C.H. (登録日: 2019-04-15, 公開日: 2019-07-24, 最終更新日: 2023-11-22)

• 主引用文献: Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X.; Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.; J.Med.Chem., 63:2114-2130, 2020; PubMed: 31244114; DOI: 10.1021/acs.jmedchem.9b00664

実験手法

X-RAY DIFFRACTION (2.1 Å)