6JRJ

The structure of co-crystals of 8r-B-EGFR T790M/C797S complex

6JRJ の概要

• エントリーDOI: 10.2210/pdb6jrj/pdb
• 分子名称: Epidermal growth factor receptor, 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one (3 entities in total)
• 機能のキーワード: egfr t790m/c797s, inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38092.53

構造登録者

Zhu, S.J.,Yun, C.H. (登録日: 2019-04-04, 公開日: 2020-04-15, 最終更新日: 2024-03-27)

• 主引用文献: Shen, J.,Zhang, T.,Zhu, S.J.,Sun, M.,Tong, L.,Lai, M.,Zhang, R.,Xu, W.,Wu, R.,Ding, J.,Yun, C.H.,Xie, H.,Lu, X.,Ding, K.; Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).; J.Med.Chem., 62:7302-7308, 2019; PubMed: 31298540; DOI: 10.1021/acs.jmedchem.9b00576

実験手法

X-RAY DIFFRACTION (2.943 Å)