6JPE
Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1
Summary for 6JPE
Entry DOI | 10.2210/pdb6jpe/pdb |
Descriptor | Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | fgfr4, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35406.54 |
Authors | |
Primary citation | Rezende Miranda, R.,Fu, Y.,Chen, X.,Perino, J.,Cao, P.,Carpten, J.,Chen, Y.,Zhang, C. Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma. J.Med.Chem., 63:11484-11497, 2020 Cited by PubMed: 33030342DOI: 10.1021/acs.jmedchem.0c00044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.601 Å) |
Structure validation
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