6JPE

Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1

6JPE の概要

• エントリーDOI: 10.2210/pdb6jpe/pdb
• 分子名称: Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: fgfr4, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35406.54

構造登録者

Chen, X.,Dai, S.,Zhou, Z.,Chen, Y. (登録日: 2019-03-26, 公開日: 2020-05-06, 最終更新日: 2023-11-22)

• 主引用文献: Rezende Miranda, R.,Fu, Y.,Chen, X.,Perino, J.,Cao, P.,Carpten, J.,Chen, Y.,Zhang, C.; Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.; J.Med.Chem., 63:11484-11497, 2020; PubMed: 33030342; DOI: 10.1021/acs.jmedchem.0c00044

実験手法

X-RAY DIFFRACTION (1.601 Å)