6JN2
Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10
Summary for 6JN2
Entry DOI | 10.2210/pdb6jn2/pdb |
Descriptor | Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific (2 entities in total) |
Functional Keywords | hdot1l, haf10, leucine zipper, heterodimer, tetramerization, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 20577.39 |
Authors | |
Primary citation | Song, X.,Yang, L.,Wang, M.,Gu, Y.,Ye, B.,Fan, Z.,Xu, R.M.,Yang, N. A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity. Proc.Natl.Acad.Sci.USA, 116:19917-19923, 2019 Cited by PubMed: 31527241DOI: 10.1073/pnas.1904672116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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