6JMF

Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4

Summary for 6JMF

Entry DOI	10.2210/pdb6jmf/pdb
Descriptor	Tyrosine-protein kinase Fes/Fps, SULFATE ION, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide, ... (4 entities in total)
Functional Keywords	fes, c-fes, tyrosine protein kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43040.24
Authors	Baba, D.,Hanzawa, H. (deposition date: 2019-03-08, release date: 2019-06-12, Last modification date: 2023-11-22)
Primary citation	Taniguchi, T.,Inagaki, H.,Baba, D.,Yasumatsu, I.,Toyota, A.,Kaneta, Y.,Kiga, M.,Iimura, S.,Odagiri, T.,Shibata, Y.,Ueda, K.,Seo, M.,Shimizu, H.,Imaoka, T.,Nakayama, K. Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. Acs Med.Chem.Lett., 10:737-742, 2019 Cited by PubMed: 31097992 DOI: 10.1021/acsmedchemlett.8b00631 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation