6JM9

cryo-EM structure of DOT1L bound to unmodified nucleosome

Summary for 6JM9

Entry DOI	10.2210/pdb6jm9/pdb
EMDB information	9843 9844
Descriptor	DNA strand I, DNA strand J, Histone H3.2, ... (8 entities in total)
Functional Keywords	histone, nucleosome, methylation, gene regulation
Biological source	synthetic construct More
Total number of polymer chains	11
Total formula weight	201592.86
Authors	Jang, S.,Song, J.J. (deposition date: 2019-03-07, release date: 2019-05-15, Last modification date: 2024-03-27)
Primary citation	Jang, S.,Kang, C.,Yang, H.S.,Jung, T.,Hebert, H.,Chung, K.Y.,Kim, S.J.,Hohng, S.,Song, J.J. Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase. Genes Dev., 33:620-625, 2019 Cited by PubMed: 30923167 DOI: 10.1101/gad.323790.118 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (7.3 Å)

Structure validation