6JKE

Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.

6JKE の概要

• エントリーDOI: 10.2210/pdb6jke/pdb
• 分子名称: Bromodomain-containing protein 2, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44485.61

構造登録者

Padmanabhan, B.,Mathur, S.,Deshmukh, P. (登録日: 2019-02-28, 公開日: 2020-07-01, 最終更新日: 2023-11-22)

• 主引用文献: Deshmukh, P.,Mathur, S.,Gangadharan, G.,Krishnappa, G.,Dalavaikodihalli Nanjaiah, N.,Padmanabhan, B.; Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma.; Biochem.J., 477:2263-2279, 2020; PubMed: 32484211; DOI: 10.1042/BCJ20200339

実験手法