Structure of SUR1 subunit bound with repaglinide

Summary for 6JB3

EMDB information9788
DescriptorATP-binding cassette sub-family C member 8 isoform X2, Repaglinide, Digitonin (3 entities in total)
Functional Keywordskatp, channel, repaglinide, kir, abc transporter, sur, membrane protein, diabetes, insulin secretagogue
Biological sourceMesocricetus auratus (Golden hamster)
Total number of polymer chains1
Total molecular weight178977.41
Chen, L.,Ding, D.,Wang, M.,Wu, J.-X.,Kang, Y. (deposition date: 2019-01-25, release date: 2019-05-22)
Primary citation
Ding, D.,Wang, M.,Wu, J.X.,Kang, Y.,Chen, L.
The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27:1848-1857.e4, 2019
PubMed: 31067468 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2019.04.050
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers90 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures