Summary for 6J63
Entry DOI | 10.2210/pdb6j63/pdb |
Descriptor | 4-hydroxyphenylpyruvate dioxygenase, FE (III) ION, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, ... (4 entities in total) |
Functional Keywords | 4-hydroxyphenylpyruvate dioxygenase, nitisinone, type i tyrosinemia, drug discovery, oxidoreductase |
Biological source | Arabidopsis thaliana (Mouse-ear cress) |
Total number of polymer chains | 4 |
Total formula weight | 197035.62 |
Authors | Yang, W.C.,Yang, G.F. (deposition date: 2019-01-13, release date: 2019-02-06, Last modification date: 2023-11-22) |
Primary citation | Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J., 286:975-990, 2019 Cited by PubMed: 30632699DOI: 10.1111/febs.14747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.624 Å) |
Structure validation
Download full validation report