Summary for 6J63
| Entry DOI | 10.2210/pdb6j63/pdb |
| Descriptor | 4-hydroxyphenylpyruvate dioxygenase, FE (III) ION, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, ... (4 entities in total) |
| Functional Keywords | 4-hydroxyphenylpyruvate dioxygenase, nitisinone, type i tyrosinemia, drug discovery, oxidoreductase |
| Biological source | Arabidopsis thaliana (Mouse-ear cress) |
| Total number of polymer chains | 4 |
| Total formula weight | 197035.62 |
| Authors | Yang, W.C.,Yang, G.F. (deposition date: 2019-01-13, release date: 2019-02-06, Last modification date: 2023-11-22) |
| Primary citation | Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J., 286:975-990, 2019 Cited by PubMed: 30632699DOI: 10.1111/febs.14747 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.624 Å) |
Structure validation
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