6J4P

Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications

Summary for 6J4P

• Entry DOI: 10.2210/pdb6j4p/pdb
• Descriptor: Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine, ... (4 entities in total)
• Functional Keywords: carboxypeptidase, tubulin, microtubule, inhibitor, epoy, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 37469.67

Authors

Wang, N.,Bao, H.,Huang, H. (deposition date: 2019-01-10, release date: 2019-05-01, Last modification date: 2023-11-22)

• Primary citation: Wang, N.,Bosc, C.,Ryul Choi, S.,Boulan, B.,Peris, L.,Olieric, N.,Bao, H.,Krichen, F.,Chen, L.,Andrieux, A.,Olieric, V.,Moutin, M.J.,Steinmetz, M.O.,Huang, H.; Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.; Nat.Struct.Mol.Biol., 26:571-582, 2019; PubMed: 31235911; DOI: 10.1038/s41594-019-0241-y

Experimental method

X-RAY DIFFRACTION (1.599 Å)